all Publications

Zhou, Z., Ma, A., Moore, T.M., Wolf, D.M., Yang, N., Tran, P., Segawa, M., Strumwasser, A.R., Ren, W., Fu, K., Wanagat, J., van der Bliek, A.M., Crosbie-Watson, R., Liesa, M., Stiles, L., Acin-Perez, R., Mahata, S., Shirihai, O., Goodarzi, M.O., Handzlik, M., Metallo, C.M., Walker, D.W., Hevener, A.L. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. (2024) Science Advances. 10(14):eadl0389. DOI: 10.1126/sciadv.adl0389

Greene, T.T., Jo, Y., Macal, M., Fang, Z., Khatri, F.S., Codrington, A.L., Kazane, K.R., Chiale, C., Akbulut, E., Swaminathan, S., Fujita, Y., Fitzgerald-Bocarsly, P., Cordes, T., Metallo, C., Scott, D.A., Zuniga, E.I. Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection. (2024) bioRxiv. DOI: 10.1101/2024.02.28.582551

Lim, E.W., Metallo, C.M. Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond. (2024) Cold Spring Harb Perspect Med. DOI: 10.1101/cshperspect.a041533

Kuhlmann-Hogan, A., Cordes, T., Xu, Z., Kuna, R.S., Traina, K.A., Robles-Oteiza, C., Ayeni, D., Kwong, E.M., Levy, S., Globig, A.M., Nobari, M.M., Cheng, G.Z., Leibel, S.L., Homer, R.J., Shaw, R.J., Metallo, C.M., Politi, K., Kaech, S.M. EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. (2024) Cancer Discovery.:OF1-OF22 DOI: 10.1158/2159-8290.CD-23-0434

O’Sullivan, A., Brady, E., Lafferty, L., O’Shea, F., O’Regan, Z., Meurs, N., Baldini, M., Gengatharan, J., Metallo, C.M., Wallace, M. Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain. (2024) Prostaglandins Leukot Essent Fatty Acids. 201:102607. DOI: 10.1016/j.plefa.2024.102607

Muta, Y., Linares, J.F., Martinez-Ordoñez, A., Duran, A., Cid-Diaz, T., Kinoshita, H., Zhang, X., Han, Q., Nakanishi, Y., Nakanishi, N., Cordes, T., Arora, G.K., Ruiz-Martinez, M., Reina-Campos, M., Kasashima, H., Yashiro, M., Maeda, K., Albaladejo-Gonzalez, A., Torres-Moreno, D., García-Solano, J., Conesa-Zamora, P., Inghirami, G., Metallo, C.M., Osborne, T.F., Diaz-Meco, M.T., Moscat, J. Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. (2023) Nature Communications. 14(1):8075. DOI: 10.1038/s41467-023-43690-5

Zhang, J., Keibler, M.A., Dong, W., Ghelfi, J., Cordes, T., Kanashova, T., Pailot, A., Linster, C.L., Dittmar, G., Metallo, C.M., Lautenschlaeger, T., Hiller, K., Stephanopoulos, G. Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. (2023) Biomedicines. 11(10). DOI: 10.3390/biomedicines11102842

Joulia, E., Metallo, C.M. Methionine and HS alter cancer-immune dialogue. (2023) Nat Metab. DOI: 10.1038/s42255-023-00862-3

Handzlik, M.K., Metallo, C.M. Sources and Sinks of Serine in Nutrition, Health, and Disease. (2023) Annu Rev Nutr. DOI: 10.1146/annurev-nutr-061021-022648

Eade, K.T., Ansell, B.R.E., Giles, S., Fallon, R., Harkins-Perry, S., Nagasaki, T., Tzaridis, S., Wallace, M., Mills, E.A., Farashi, S., Johnson, A., Sauer, L., Hart, B., Rubio, E.D., Bahlo, M., Metallo, C., Allikmets, R., Gantner, M.L., Bernstein, P.S., Friedlander, M. iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function. (2023) Journal of Clinical Investigation. 133(9). DOI: 10.1172/JCI163771

Kuna, R.S., Kumar, A., Wessendorf-Rodriguez, K.A., Galvez, H., Green, C.R., McGregor, G.H., Cordes, T., Shaw, R.J., Svensson, R.U., Metallo, C.M. Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress. (2023) Science Advances. 9(18):eadf0138. DOI: 10.1126/sciadv.adf0138

Heyden, K.E., Fiddler, J.L., Xiu, Y., Malysheva, O.V., Handzlik, M.K., Phinney, W.N., Stiles, L., Stabler, S.P., Metallo, C.M., Caudill, M.A., Field, M.S. Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity. (2023) PNAS Nexus. 2(4):pgad105. DOI: 10.1093/pnasnexus/pgad105

Kuhlmann-Hogan, A., Cordes, T., Xu, Z., Traina, K.A., Robles-Oteíza, C., Ayeni, D., Kwong, E.M., Levy, S.R., Nobari, M., Cheng, G.Z., Shaw, R., Leibel, S.L., Metallo, C.M., Politi, K., Kaech, S.M. EGFR lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. (2023) bioRxiv. DOI: 10.1101/2023.04.15.536974

Trieger, G.W., Pessentheiner, A.R., Purcell, S.C., Green, C.R., DeForest, N., Willert, K., Majithia, A.R., Metallo, C.M., Godula, K., Gordts, P.L.S.M. Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism. (2023) Journal of Biological Chemistry.:104611 DOI: 10.1016/j.jbc.2023.104611

Green, C.R., Bonelli, R., Ansell, B.R.E., Tzaridis, S., Handzlik, M.K., McGregor, G.H., Hart, B., Trombley, J., Reilly, M.M., Bernstein, P.S., Egan, C., Fruttiger, M., Wallace, M., Bahlo, M., Friedlander, M., Metallo, C.M., Gantner, M.L. Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease. (2023) Molecular Metabolism.:101716 DOI: 10.1016/j.molmet.2023.101716

Wortham, M., Liu, F., Harrington, A.R., Fleischman, J.Y., Wallace, M., Mulas, F., Mallick, M., Vinckier, N.K., Cross, B.R., Chiou, J., Patel, N.A., Sui, Y., McGrail, C., Jun, Y., Wang, G., Jhala, U.S., Schüle, R., Shirihai, O.S., Huising, M.O., Gaulton, K.J., Metallo, C.M., Sander, M. Nutrient regulation of the islet epigenome controls adaptive insulin secretion. (2023) Journal of Clinical Investigation. DOI: 10.1172/JCI165208

Handzlik, M.K., Gengatharan, J.M., Frizzi, K.E., McGregor, G.H., Martino, C., Rahman, G., Gonzalez, A., Moreno, A.M., Green, C.R., Guernsey, L.S., Lin, T., Tseng, P., Ideguchi, Y., Fallon, R.J., Chaix, A., Panda, S., Mali, P., Wallace, M., Knight, R., Gantner, M.L., Calcutt, N.A., Metallo, C.M. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. (2023) Nature. DOI: 10.1038/s41586-022-05637-6

Laurila, P.P., Wohlwend, M., Imamura de Lima, T., Luan, P., Herzig, S., Zanou, N., Crisol, B., Bou-Sleiman, M., Porcu, E., Gallart-Ayala, H., Handzlik, M.K., Wang, Q., Jain, S., D’Amico, D., Salonen, M., Metallo, C.M., Kutalik, Z., Eichmann, T.O., Place, N., Ivanisevic, J., Lahti, J., Eriksson, J.G., Auwerx, J. Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia. (2022) Nat Aging. 2(12):1159-1175. DOI: 10.1038/s43587-022-00309-6

Su, H., Yang, F., Fu, R., Trinh, B., Sun, N., Liu, J., Kumar, A., Baglieri, J., Siruno, J., Le, M., Li, Y., Dozier, S., Nair, A., Filliol, A., Sinchai, N., Rosenthal, S.B., Santini, J., Metallo, C.M., Molina, A., Schwabe, R.F., Lowy, A.M., Brenner, D., Sun, B., Karin, M. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. (2022) Nature. DOI: 10.1038/s41586-022-05169-z

Cordes, T., Kuna, R.S., McGregor, G.H., Khare, S.V., Gengatharan, J., Muthusamy, T., Metallo, C.M. 1-deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells. (2022) Journal of Lipid Research.:100281 DOI: 10.1016/j.jlr.2022.100281

Martino, C., Zaramela, L.S., Gao, B., Embree, M., Tarasova, J., Parker, S.J., Wang, Y., Chu, H., Chen, P., Lee, K.C., Galzerani, D.D., Gengatharan, J.M., Lekbua, A., Neal, M., Knight, R., Tsukamoto, H., Metallo, C.M., Schnabl, B., Zengler, K. Acetate reprograms gut microbiota during alcohol consumption. (2022) Nature Communications. 13(1):4630. DOI: 10.1038/s41467-022-31973-2

He, W., Henne, A., Lauterbach, M., Geißmar, E., Nikolka, F., Kho, C., Heinz, A., Dostert, C., Grusdat, M., Cordes, T., Härm, J., Goldmann, O., Ewen, A., Verschueren, C., Blay-Cadanet, J., Geffers, R., Garritsen, H., Kneiling, M., Holm, C.K., Metallo, C.M., Medina, E., Abdullah, Z., Latz, E., Brenner, D., Hiller, K. Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. (2022) Nat Metab. DOI: 10.1038/s42255-022-00565-1

Perea-Gil, I., Seeger, T., Bruyneel, A.A.N., Termglinchan, V., Monte, E., Lim, E.W., Vadgama, N., Furihata, T., Gavidia, A.A., Arthur Ataam, J., Bharucha, N., Martinez-Amador, N., Ameen, M., Nair, P., Serrano, R., Kaur, B., Feyen, D.A.M., Diecke, S., Snyder, M.P., Metallo, C.M., Mercola, M., Karakikes, I. Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. (2022) Eur Heart J. DOI: 10.1093/eurheartj/ehac305

Linares, J.F., Cid-Diaz, T., Duran, A., Osrodek, M., Martinez-Ordoñez, A., Reina-Campos, M., Kuo, H.H., Elemento, O., Martin, M.L., Cordes, T., Thompson, T.C., Metallo, C.M., Moscat, J., Diaz-Meco, M.T. The lactate-NAD axis activates cancer-associated fibroblasts by downregulating p62. (2022) Cell Reports. 39(6):110792. DOI: 10.1016/j.celrep.2022.110792

Casanova-Vallve, N., Duglan, D., Vaughan, M.E., Pariollaud, M., Handzlik, M.K., Fan, W., Yu, R.T., Liddle, C., Downes, M., Delezie, J., Mello, R., Chan, A.B., Westermark, P.O., Metallo, C.M., Evans, R.M., Lamia, K.A. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. (2022) Molecular Metabolism.:101504 DOI: 10.1016/j.molmet.2022.101504

Parekh, U., McDonald, D., Dailamy, A., Wu, Y., Cordes, T., Zhang, K., Tipps, A., Metallo, C., Mali, P. Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas. (2021) iScience. 24(10):103149. DOI: 10.1016/j.isci.2021.103149

Lim, E.W., Handzlik, M.K., Trefts, E., Gengatharan, J.M., Pondevida, C.M., Shaw, R.J., Metallo, C.M. Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in mice. (2021) Science Advances. 7(42):eabj4077. DOI: 10.1126/sciadv.abj4077

Kumar, A., Cordes, T., Thalacker-Mercer, A.E., Pajor, A.M., Murphy, A.N., Metallo, C.M. NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions. (2021) Cell Reports. 36(11):109701. DOI: 10.1016/j.celrep.2021.109701

Yebra, M., Bhargava, S., Kumar, A., Burgoyne, A.M., Tang, C.M., Yoon, H., Banerjee, S., Aguilera, J., Cordes, T., Sheth, V., Noh, S., Ustoy, R., Li, S., Advani, S.J., Corless, C.L., Heinrich, M.C., Kurzrock, R., Lippman, S.M., Fanta, P.T., Harismendy, O., Metallo, C., Sicklick, J.K. Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models For Predicting Therapeutic Response. (2021) Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-21-2092

Ravi, A., Palamiuc, L., Loughran, R.M., Triscott, J., Arora, G.K., Kumar, A., Tieu, V., Pauli, C., Reist, M., Lew, R.J., Houlihan, S.L., Fellmann, C., Metallo, C., Rubin, M.A., Emerling, B.M. PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. (2021) Developmental Cell. 56(11):1661-1676.e10. DOI: 10.1016/j.devcel.2021.04.019

Su, H., Yang, F., Fu, R., Li, X., French, R., Mose, E., Pu, X., Trinh, B., Kumar, A., Liu, J., Antonucci, L., Todoric, J., Liu, Y., Hu, Y., Diaz-Meco, M.T., Moscat, J., Metallo, C.M., Lowy, A.M., Sun, B., Karin, M. Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. (2021) Cancer Cell. 39(5):678-693.e11. DOI: 10.1016/j.ccell.2021.02.016

Sawh, M.C., Wallace, M., Shapiro, E., Goyal, N.P., Newton, K.P., Yu, E.L., Bross, C., Durelle, J., Knott, C., Gangoiti, J.A., Barshop, B.A., Gengatharan, J.M., Meurs, N., Schlein, A., Middleton, M.S., Sirlin, C.B., Metallo, C.M., Schwimmer, J.B. Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children. (2021) J Pediatr Gastroenterol Nutr. 72(4):e90-e96. DOI: 10.1097/MPG.0000000000003040

Cordes, T., Metallo, C.M. Exploring the evolutionary roots and physiological function of itaconate. (2021) Curr Opin Biotechnol. 68:144-150. DOI: 10.1016/j.copbio.2020.11.005

Eade, K., Gantner, M.L., Hostyk, J.A., Nagasaki, T., Giles, S., Fallon, R., Harkins-Perry, S., Baldini, M., Lim, E.W., Scheppke, L., Dorrell, M.I., Cai, C., Baugh, E.H., Wolock, C.J., Wallace, M., Berlow, R.B., Goldstein, D.B., Metallo, C.M., Friedlander, M., Allikmets, R. Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease. (2021) Nat Metab. 3(3):366-377. DOI: 10.1038/s42255-021-00361-3

Cordes, T., Metallo, C.M. Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase. (2021) Metabolites. 11(2). DOI: 10.3390/metabo11020117

Lee, Y.M., Mu, A., Wallace, M., Gengatharan, J.M., Furst, A.J., Bode, L., Metallo, C.M., Ayres, J.S. Microbiota control of maternal behavior regulates early postnatal growth of offspring. (2021) Science Advances. 7(5). DOI: 10.1126/sciadv.abe6563

Gheller, B.J., Blum, J.E., Lim, E.W., Handzlik, M.K., Hannah Fong, E.H., Ko, A.C., Khanna, S., Gheller, M.E., Bender, E.L., Alexander, M.S., Stover, P.J., Field, M.S., Cosgrove, B.D., Metallo, C.M., Thalacker-Mercer, A.E. Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function. (2021) Molecular Metabolism. 43:101106. DOI: 10.1016/j.molmet.2020.101106

Huh, J.Y., Reilly, S.M., Abu-Odeh, M., Murphy, A.N., Mahata, S.K., Zhang, J., Cho, Y., Seo, J.B., Hung, C.W., Green, C.R., Metallo, C.M., Saltiel, A.R. TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. (2020) Cell Metabolism. 32(6):1012-1027.e7. DOI: 10.1016/j.cmet.2020.10.010

Wallace, M., Metallo, C.M. Tracing insights into de novo lipogenesis in liver and adipose tissues. (2020) Seminars in Cell & Developmental Biology. 108:65-71. DOI: 10.1016/j.semcdb.2020.02.012

Gheller, M.E., Vermeylen, F., Handzlik, M.K., Gheller, B.J., Bender, E., Metallo, C., Aydemir, T.B., Smriga, M., Thalacker-Mercer, A.E. Tolerance to graded dosages of histidine supplementation in healthy human adults. (2020) Am J Clin Nutr. 112(5):1358-1367. DOI: 10.1093/ajcn/nqaa210

Rudd, A.K., Mittal, N., Lim, E.W., Metallo, C.M., Devaraj, N.K. A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells. (2020) Journal of the American Chemical Society. 142(42):17887-17891. DOI: 10.1021/jacs.0c06652

Todoric, J., Di Caro, G., Reibe, S., Henstridge, D.C., Green, C.R., Vrbanac, A., Ceteci, F., Conche, C., McNulty, R., Shalapour, S., Taniguchi, K., Meikle, P.J., Watrous, J.D., Moranchel, R., Najhawan, M., Jain, M., Liu, X., Kisseleva, T., Diaz-Meco, M.T., Moscat, J., Knight, R., Greten, F.R., Lau, L.F., Metallo, C.M., Febbraio, M.A., Karin, M. Fructose stimulated de novo lipogenesis is promoted by inflammation. (2020) Nat Metab. 2(10):1034-1045. DOI: 10.1038/s42255-020-0261-2

Muthusamy, T., Cordes, T., Handzlik, M.K., You, L., Lim, E.W., Gengatharan, J., Pinto, A.F.M., Badur, M.G., Kolar, M.J., Wallace, M., Saghatelian, A., Metallo, C.M. Serine restriction alters sphingolipid diversity to constrain tumour growth. (2020) Nature. 586(7831):790-795. DOI: 10.1038/s41586-020-2609-x

Henke, C., Töllner, K., van Dijk, R.M., Miljanovic, N., Cordes, T., Twele, F., Bröer, S., Ziesak, V., Rohde, M., Hauck, S.M., Vogel, C., Welzel, L., Schumann, T., Willmes, D.M., Kurzbach, A., El-Agroudy, N.N., Bornstein, S.R., Schneider, S.A., Jordan, J., Potschka, H., Metallo, C.M., Köhling, R., Birkenfeld, A.L., Löscher, W. Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus. (2020) Neurobiol Dis. 143:105018. DOI: 10.1016/j.nbd.2020.105018

Gaglio, D., Bonanomi, M., Valtorta, S., Bharat, R., Ripamonti, M., Conte, F., Fiscon, G., Righi, N., Napodano, E., Papa, F., Raccagni, I., Parker, S.J., Cifola, I., Camboni, T., Paci, P., Colangelo, A.M., Vanoni, M., Metallo, C.M., Moresco, R.M., Alberghina, L. Disruption of redox homeostasis for combinatorial drug efficacy in tumors as revealed by metabolic connectivity profiling. (2020) Cancer Metab. 8:22. DOI: 10.1186/s40170-020-00227-4

Kudo, Y., Sugimoto, M., Arias, E., Kasashima, H., Cordes, T., Linares, J.F., Duran, A., Nakanishi, Y., Nakanishi, N., L’Hermitte, A., Campos, A., Senni, N., Rooslid, T., Roberts, L.R., Cuervo, A.M., Metallo, C.M., Karin, M., Diaz-Meco, M.T., Moscat, J. PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. (2020) Cancer Cell. 38(2):247-262.e11. DOI: 10.1016/j.ccell.2020.05.018

Feyen, D.A.M., McKeithan, W.L., Bruyneel, A.A.N., Spiering, S., Hörmann, L., Ulmer, B., Zhang, H., Briganti, F., Schweizer, M., Hegyi, B., Liao, Z., Pölönen, R.P., Ginsburg, K.S., Lam, C.K., Serrano, R., Wahlquist, C., Kreymerman, A., Vu, M., Amatya, P.L., Behrens, C.S., Ranjbarvaziri, S., Maas, R.G.C., Greenhaw, M., Bernstein, D., Wu, J.C., Bers, D.M., Eschenhagen, T., Metallo, C.M., Mercola, M. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. (2020) Cell Reports. 32(3):107925. DOI: 10.1016/j.celrep.2020.107925

Kumar, A., Mitchener, J., King, Z.A., Metallo, C.M. Escher-Trace: a web application for pathway-based visualization of stable isotope tracing data. (2020) BMC Bioinformatics. 21(1):297. DOI: 10.1186/s12859-020-03632-0

Vaughan, M.E., Wallace, M., Handzlik, M.K., Chan, A.B., Metallo, C.M., Lamia, K.A. Cryptochromes Suppress HIF1α in Muscles. (2020) iScience. 23(7):101338. DOI: 10.1016/j.isci.2020.101338

Hong, S., Dechaumphai, E., Green, C.R., Lal, R., Murphy, A.N., Metallo, C.M., Chen, R. Sub-nanowatt microfluidic single-cell calorimetry. (2020) Nature Communications. 11(1):2982. DOI: 10.1038/s41467-020-16697-5

Liu, X., Olszewski, K., Zhang, Y., Lim, E.W., Shi, J., Zhang, X., Zhang, J., Lee, H., Koppula, P., Lei, G., Zhuang, L., You, M.J., Fang, B., Li, W., Metallo, C.M., Poyurovsky, M.V., Gan, B. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. (2020) Nature Cell Biology. 22(4):476-486. DOI: 10.1038/s41556-020-0496-x

Cordes, T., Lucas, A., Divakaruni, A.S., Murphy, A.N., Cabrales, P., Metallo, C.M. Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. (2020) Molecular Metabolism. 32:122-135. DOI: 10.1016/j.molmet.2019.11.019

Cordes, T., Metallo, C.M. Statins Limit Coenzyme Q Synthesis and Metabolically Synergize with MEK Inhibition in Pancreatic Tumors. (2020) Cancer Research. 80(2):151-152. DOI: 10.1158/0008-5472.CAN-19-3415

Lim, E.W., Parker, S.J., Metallo, C.M. Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells. (2020) Methods in Molecular Biology. 2088:51-71. DOI: 10.1007/978-1-0716-0159-4_4

Gao, X., Zhao, L., Liu, S., Li, Y., Xia, S., Chen, D., Wang, M., Wu, S., Dai, Q., Vu, H., Zacharias, L., DeBerardinis, R., Lim, E., Metallo, C., Boggon, T.J., Lonial, S., Lin, R., Mao, H., Pan, Y., Shan, C., Chen, J. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. (2019) Molecular Cell. 76(6):857-871.e9. DOI: 10.1016/j.molcel.2019.09.007

Gantner, M.L., Eade, K., Wallace, M., Handzlik, M.K., Fallon, R., Trombley, J., Bonelli, R., Giles, S., Harkins-Perry, S., Heeren, T.F.C., Sauer, L., Ideguchi, Y., Baldini, M., Scheppke, L., Dorrell, M.I., Kitano, M., Hart, B.J., Cai, C., Nagasaki, T., Badur, M.G., Okada, M., Woods, S.M., Egan, C., Gillies, M., Guymer, R., Eichler, F., Bahlo, M., Fruttiger, M., Allikmets, R., Bernstein, P.S., Metallo, C.M., Friedlander, M. Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. (2019) New England Journal of Medicine. 381(15):1422-1433. DOI: 10.1056/NEJMoa1815111

Jung, S.M., Hung, C.M., Hildebrand, S.R., Sanchez-Gurmaches, J., Martinez-Pastor, B., Gengatharan, J.M., Wallace, M., Mukhopadhyay, D., Martinez Calejman, C., Luciano, A.K., Hsiao, W.Y., Tang, Y., Li, H., Daniels, D.L., Mostoslavsky, R., Metallo, C.M., Guertin, D.A. Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. (2019) Molecular Cell. 75(4):807-822.e8. DOI: 10.1016/j.molcel.2019.07.023

Ramms, B., Patel, S., Nora, C., Pessentheiner, A.R., Chang, M.W., Green, C.R., Golden, G.J., Secrest, P., Krauss, R.M., Metallo, C.M., Benner, C., Alexander, V.J., Witztum, J.L., Tsimikas, S., Esko, J.D., Gordts, P.L.S.M. ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. (2019) Journal of Lipid Research. 60(8):1379-1395. DOI: 10.1194/jlr.M093740

Velez, D.O., Ranamukhaarachchi, S.K., Kumar, A., Modi, R.N., Lim, E.W., Engler, A.J., Metallo, C.M., Fraley, S.I. 3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress. (2019) Integr Biol (Camb). 11(5):221-234. DOI: 10.1093/intbio/zyz019

Reina-Campos, M., Linares, J.F., Duran, A., Cordes, T., L’Hermitte, A., Badur, M.G., Bhangoo, M.S., Thorson, P.K., Richards, A., Rooslid, T., Garcia-Olmo, D.C., Nam-Cha, S.Y., Salinas-Sanchez, A.S., Eng, K., Beltran, H., Scott, D.A., Metallo, C.M., Moscat, J., Diaz-Meco, M.T. Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer. (2019) Cancer Cell. 35(3):385-400.e9. DOI: 10.1016/j.ccell.2019.01.018

Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M.G., Lin, T., Shokhirev, M.N., Pinto, A.F.M., Ross, D.S., Saghatelian, A., Panda, S., Dow, L.E., Metallo, C.M., Shaw, R.J. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. (2019) Cell Reports. 26(1):192-208.e6. DOI: 10.1016/j.celrep.2018.12.036

Cordes, T., Metallo, C.M. Quantifying Intermediary Metabolism and Lipogenesis in Cultured Mammalian Cells Using Stable Isotope Tracing and Mass Spectrometry. (2019) Methods in Molecular Biology. 1978:219-241. DOI: 10.1007/978-1-4939-9236-2_14

Wortham, M., Benthuysen, J.R., Wallace, M., Savas, J.N., Mulas, F., Divakaruni, A.S., Liu, F., Albert, V., Taylor, B.L., Sui, Y., Saez, E., Murphy, A.N., Yates, J.R., Metallo, C.M., Sander, M. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function. (2018) Cell Reports. 25(10):2904-2918.e8. DOI: 10.1016/j.celrep.2018.11.031

Badur, M.G., Muthusamy, T., Parker, S.J., Ma, S., McBrayer, S.K., Cordes, T., Magana, J.H., Guan, K.L., Metallo, C.M. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. (2018) Cell Reports. 25(6):1680. DOI: 10.1016/j.celrep.2018.10.099

Wallace, M., Green, C.R., Roberts, L.S., Lee, Y.M., McCarville, J.L., Sanchez-Gurmaches, J., Meurs, N., Gengatharan, J.M., Hover, J.D., Phillips, S.A., Ciaraldi, T.P., Guertin, D.A., Cabrales, P., Ayres, J.S., Nomura, D.K., Loomba, R., Metallo, C.M. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. (2018) Nature Chemical Biology. 14(11):1021-1031. DOI: 10.1038/s41589-018-0132-2

Badur, M.G., Muthusamy, T., Parker, S.J., Ma, S., McBrayer, S.K., Cordes, T., Magana, J.H., Guan, K.L., Metallo, C.M. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. (2018) Cell Reports. 25(4):1018-1026. DOI: 10.1016/j.celrep.2018.09.074

McBrayer, S.K., Mayers, J.R., DiNatale, G.J., Shi, D.D., Khanal, J., Chakraborty, A.A., Sarosiek, K.A., Briggs, K.J., Robbins, A.K., Sewastianik, T., Shareef, S.J., Olenchock, B.A., Parker, S.J., Tateishi, K., Spinelli, J.B., Islam, M., Haigis, M.C., Looper, R.E., Ligon, K.L., Bernstein, B.E., Carrasco, R.D., Cahill, D.P., Asara, J.M., Metallo, C.M., Yennawar, N.H., Vander Heiden, M.G., Kaelin, W.G. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. (2018) Cell. 175(1):101-116.e25. DOI: 10.1016/j.cell.2018.08.038

Sessions, A.O., Min, P., Cordes, T., Weickert, B.J., Divakaruni, A.S., Murphy, A.N., Metallo, C.M., Engler, A.J. Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span. (2018) APL Bioeng. 2(3). DOI: 10.1063/1.5019592

Skorobogatko, Y., Dragan, M., Cordon, C., Reilly, S.M., Hung, C.W., Xia, W., Zhao, P., Wallace, M., Lackey, D.E., Chen, X.W., Osborn, O., Bogner-Strauss, J.G., Theodorescu, D., Metallo, C.M., Olefsky, J.M., Saltiel, A.R. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. (2018) Proceedings of the National Academy of Sciences of the United States of America. 115(30):7819-7824. DOI: 10.1073/pnas.1801050115

Zhao, D., Badur, M.G., Luebeck, J., Magaña, J.H., Birmingham, A., Sasik, R., Ahn, C.S., Ideker, T., Metallo, C.M., Mali, P. Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. (2018) Molecular Cell. 69(4):699-708.e7. DOI: 10.1016/j.molcel.2018.01.017

Badur, M.G., Metallo, C.M. Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease. (2018) Metab Eng. 45:95-108. DOI: 10.1016/j.ymben.2017.11.013

Jin, L., Chun, J., Pan, C., Kumar, A., Zhang, G., Ha, Y., Li, D., Alesi, G.N., Kang, Y., Zhou, L., Yu, W.M., Magliocca, K.R., Khuri, F.R., Qu, C.K., Metallo, C., Owonikoko, T.K., Kang, S. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. (2018) Molecular Cell. 69(1):87-99.e7. DOI: 10.1016/j.molcel.2017.11.025

Linares, J.F., Cordes, T., Duran, A., Reina-Campos, M., Valencia, T., Ahn, C.S., Castilla, E.A., Moscat, J., Metallo, C.M., Diaz-Meco, M.T. ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. (2017) Cell Metabolism. 26(6):817-829.e6. DOI: 10.1016/j.cmet.2017.09.001

Parker, S.J., Svensson, R.U., Divakaruni, A.S., Lefebvre, A.E., Murphy, A.N., Shaw, R.J., Metallo, C.M. LKB1 promotes metabolic flexibility in response to energy stress. (2017) Metab Eng. 43(Pt B):208-217. DOI: 10.1016/j.ymben.2016.12.010

Metallo, C.M., Deberardinis, R.J. Engineering approaches to study cancer metabolism. (2017) Metab Eng. 43(Pt B):93. DOI: 10.1016/j.ymben.2017.09.002

Zarei, M., Lal, S., Parker, S.J., Nevler, A., Vaziri-Gohar, A., Dukleska, K., Mambelli-Lisboa, N.C., Moffat, C., Blanco, F.F., Chand, S.N., Jimbo, M., Cozzitorto, J.A., Jiang, W., Yeo, C.J., Londin, E.R., Seifert, E.L., Metallo, C.M., Brody, J.R., Winter, J.M. Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. (2017) Cancer Research. 77(16):4460-4471. DOI: 10.1158/0008-5472.CAN-17-0015

Divakaruni, A.S., Wallace, M., Buren, C., Martyniuk, K., Andreyev, A.Y., Li, E., Fields, J.A., Cordes, T., Reynolds, I.J., Bloodgood, B.L., Raymond, L.A., Metallo, C.M., Murphy, A.N. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. (2017) Journal of Cell Biology. 216(4):1091-1105. DOI: 10.1083/jcb.201612067

Cordes, T., Metallo, C.M. Tracing insights into human metabolism using chemical engineering approaches. (2016) Curr Opin Chem Eng. 14:72-81. DOI: 10.1016/j.coche.2016.08.019

Zhao, S., Torres, A., Henry, R.A., Trefely, S., Wallace, M., Lee, J.V., Carrer, A., Sengupta, A., Campbell, S.L., Kuo, Y.M., Frey, A.J., Meurs, N., Viola, J.M., Blair, I.A., Weljie, A.M., Metallo, C.M., Snyder, N.W., Andrews, A.J., Wellen, K.E. ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. (2016) Cell Reports. 17(4):1037-1052. DOI: 10.1016/j.celrep.2016.09.069

Svensson, R.U., Parker, S.J., Eichner, L.J., Kolar, M.J., Wallace, M., Brun, S.N., Lombardo, P.S., Van Nostrand, J.L., Hutchins, A., Vera, L., Gerken, L., Greenwood, J., Bhat, S., Harriman, G., Westlin, W.F., Harwood, H.J., Saghatelian, A., Kapeller, R., Metallo, C.M., Shaw, R.J. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. (2016) Nature Medicine. 22(10):1108-1119. DOI: 10.1038/nm.4181

Huber, A.L., Papp, S.J., Chan, A.B., Henriksson, E., Jordan, S.D., Kriebs, A., Nguyen, M., Wallace, M., Li, Z., Metallo, C.M., Lamia, K.A. CRY2 and FBXL3 Cooperatively Degrade c-MYC. (2016) Molecular Cell. 64(4):774-789. DOI: 10.1016/j.molcel.2016.10.012

Zhang, H., Badur, M.G., Divakaruni, A.S., Parker, S.J., Jäger, C., Hiller, K., Murphy, A.N., Metallo, C.M. Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. (2016) Cell Reports. 16(6):1536-1547. DOI: 10.1016/j.celrep.2016.06.102

Cordes, T., Wallace, M., Michelucci, A., Divakaruni, A.S., Sapcariu, S.C., Sousa, C., Koseki, H., Cabrales, P., Murphy, A.N., Hiller, K., Metallo, C.M. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. (2016) Journal of Biological Chemistry. 291(27):14274-14284. DOI: 10.1074/jbc.M115.685792

Jiang, L., Shestov, A.A., Swain, P., Yang, C., Parker, S.J., Wang, Q.A., Terada, L.S., Adams, N.D., McCabe, M.T., Pietrak, B., Schmidt, S., Metallo, C.M., Dranka, B.P., Schwartz, B., DeBerardinis, R.J. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. (2016) Nature. 532(7598):255-8. DOI: 10.1038/nature17393

Parker, S.J., Metallo, C.M. Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics. (2016) Molecular Cell. 61(2):185-6. DOI: 10.1016/j.molcel.2016.01.006

Green, C.R., Wallace, M., Divakaruni, A.S., Phillips, S.A., Murphy, A.N., Ciaraldi, T.P., Metallo, C.M. Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis. (2016) Nature Chemical Biology. 12(1):15-21. DOI: 10.1038/nchembio.1961

Lussey-Lepoutre, C., Hollinshead, K.E., Ludwig, C., Menara, M., Morin, A., Castro-Vega, L.J., Parker, S.J., Janin, M., Martinelli, C., Ottolenghi, C., Metallo, C., Gimenez-Roqueplo, A.P., Favier, J., Tennant, D.A. Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. (2015) Nature Communications. 6:8784. DOI: 10.1038/ncomms9784

Badur, M.G., Zhang, H., Metallo, C.M. Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance. (2015) Biotechnol J. 10(10):1600-11. DOI: 10.1002/biot.201400749

Parker, S.J., Metallo, C.M. Metabolic consequences of oncogenic IDH mutations. (2015) Pharmacol Ther. 152:54-62. DOI: 10.1016/j.pharmthera.2015.05.003

Buescher, J.M., Antoniewicz, M.R., Boros, L.G., Burgess, S.C., Brunengraber, H., Clish, C.B., DeBerardinis, R.J., Feron, O., Frezza, C., Ghesquiere, B., Gottlieb, E., Hiller, K., Jones, R.G., Kamphorst, J.J., Kibbey, R.G., Kimmelman, A.C., Locasale, J.W., Lunt, S.Y., Maddocks, O.D., Malloy, C., Metallo, C.M., Meuillet, E.J., Munger, J., Nöh, K., Rabinowitz, J.D., Ralser, M., Sauer, U., Stephanopoulos, G., St-Pierre, J., Tennant, D.A., Wittmann, C., Vander Heiden, M.G., Vazquez, A., Vousden, K., Young, J.D., Zamboni, N., Fendt, S.M. A roadmap for interpreting (13)C metabolite labeling patterns from cells. (2015) Curr Opin Biotechnol. 34:189-201. DOI: 10.1016/j.copbio.2015.02.003

Metallo, C.M. Metabolic Analysis Using Stable Isotopes. Preface. (2015) Methods Enzymol. 561:xv-xvi. DOI: 10.1016/S0076-6879(15)00482-6

Ahn, C.S., Metallo, C.M. Mitochondria as biosynthetic factories for cancer proliferation. (2015) Cancer Metab. 3(1):1. DOI: 10.1186/s40170-015-0128-2

Vacanti, N.M., Divakaruni, A.S., Green, C.R., Parker, S.J., Henry, R.R., Ciaraldi, T.P., Murphy, A.N., Metallo, C.M. Regulation of substrate utilization by the mitochondrial pyruvate carrier. (2014) Molecular Cell. 56(3):425-435. DOI: 10.1016/j.molcel.2014.09.024

Sourjik, V., Metallo, C. Editorial overview: Systems biology: Advances in multi-scale systems biology applications. (2014) Curr Opin Biotechnol. 28:vi-viii. DOI: 10.1016/j.copbio.2014.06.016

Valencia, T., Kim, J.Y., Abu-Baker, S., Moscat-Pardos, J., Ahn, C.S., Reina-Campos, M., Duran, A., Castilla, E.A., Metallo, C.M., Diaz-Meco, M.T., Moscat, J. Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. (2014) Cancer Cell. 26(1):121-135. DOI: 10.1016/j.ccr.2014.05.004

Lewis, C.A., Parker, S.J., Fiske, B.P., McCloskey, D., Gui, D.Y., Green, C.R., Vokes, N.I., Feist, A.M., Vander Heiden, M.G., Metallo, C.M. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. (2014) Molecular Cell. 55(2):253-63. DOI: 10.1016/j.molcel.2014.05.008

Heinrichsen, E.T., Zhang, H., Robinson, J.E., Ngo, J., Diop, S., Bodmer, R., Joiner, W.J., Metallo, C.M., Haddad, G.G. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. (2014) Molecular Metabolism. 3(1):42-54. DOI: 10.1016/j.molmet.2013.10.003

Commisso, C., Davidson, S.M., Soydaner-Azeloglu, R.G., Parker, S.J., Kamphorst, J.J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J.A., Thompson, C.B., Rabinowitz, J.D., Metallo, C.M., Vander Heiden, M.G., Bar-Sagi, D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. (2013) Nature. 497(7451):633-7. DOI: 10.1038/nature12138

Hiller, K., Wegner, A., Weindl, D., Cordes, T., Metallo, C.M., Kelleher, J.K., Stephanopoulos, G. NTFD–a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data. (2013) Bioinformatics . 29(9):1226-8. DOI: 10.1093/bioinformatics/btt119

Metallo, C.M., Vander Heiden, M.G. Understanding metabolic regulation and its influence on cell physiology. (2013) Molecular Cell. 49(3):388-98. DOI: 10.1016/j.molcel.2013.01.018

Hiller, K., Metallo, C.M. Profiling metabolic networks to study cancer metabolism. (2013) Curr Opin Biotechnol. 24(1):60-8. DOI: 10.1016/j.copbio.2012.11.001

Vacanti, N.M., Metallo, C.M. Exploring metabolic pathways that contribute to the stem cell phenotype. (2013) Biochimica et Biophysica Acta. 1830(2):2361-9. DOI: 10.1016/j.bbagen.2012.08.007

Metallo, C.M. Expanding the reach of cancer metabolomics. (2012) Cancer Prevention Research. 5(12):1337-40. DOI: 10.1158/1940-6207.CAPR-12-0433

Anastasiou, D., Yu, Y., Israelsen, W.J., Jiang, J.K., Boxer, M.B., Hong, B.S., Tempel, W., Dimov, S., Shen, M., Jha, A., Yang, H., Mattaini, K.R., Metallo, C.M., Fiske, B.P., Courtney, K.D., Malstrom, S., Khan, T.M., Kung, C., Skoumbourdis, A.P., Veith, H., Southall, N., Walsh, M.J., Brimacombe, K.R., Leister, W., Lunt, S.Y., Johnson, Z.R., Yen, K.E., Kunii, K., Davidson, S.M., Christofk, H.R., Austin, C.P., Inglese, J., Harris, M.H., Asara, J.M., Stephanopoulos, G., Salituro, F.G., Jin, S., Dang, L., Auld, D.S., Park, H.W., Cantley, L.C., Thomas, C.J., Vander Heiden, M.G. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. (2012) Nature Chemical Biology. 8(10):839-47. DOI: 10.1038/nchembio.1060

Walther, J.L., Metallo, C.M., Zhang, J., Stephanopoulos, G. Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells. (2012) Metab Eng. 14(2):162-71. DOI: 10.1016/j.ymben.2011.12.004

Metallo, C.M., Gameiro, P.A., Bell, E.L., Mattaini, K.R., Yang, J., Hiller, K., Jewell, C.M., Johnson, Z.R., Irvine, D.J., Guarente, L., Kelleher, J.K., Vander Heiden, M.G., Iliopoulos, O., Stephanopoulos, G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. (2011) Nature. 481(7381):380-4. DOI: 10.1038/nature10602

Gaglio, D., Metallo, C.M., Gameiro, P.A., Hiller, K., Danna, L.S., Balestrieri, C., Alberghina, L., Stephanopoulos, G., Chiaradonna, F. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. (2011) Mol Syst Biol. 7:523. DOI: 10.1038/msb.2011.56

Grassian, A.R., Metallo, C.M., Coloff, J.L., Stephanopoulos, G., Brugge, J.S. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. (2011) Genes & Development. 25(16):1716-33. DOI: 10.1101/gad.16771811

Locasale, J.W., Grassian, A.R., Melman, T., Lyssiotis, C.A., Mattaini, K.R., Bass, A.J., Heffron, G., Metallo, C.M., Muranen, T., Sharfi, H., Sasaki, A.T., Anastasiou, D., Mullarky, E., Vokes, N.I., Sasaki, M., Beroukhim, R., Stephanopoulos, G., Ligon, A.H., Meyerson, M., Richardson, A.L., Chin, L., Wagner, G., Asara, J.M., Brugge, J.S., Cantley, L.C., Vander Heiden, M.G. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. (2011) Nature Genetics. 43(9):869-74. DOI: 10.1038/ng.890

Hiller, K., Metallo, C., Stephanopoulos, G. Elucidation of cellular metabolism via metabolomics and stable-isotope assisted metabolomics. (2011) Curr Pharm Biotechnol. 12(7):1075-1086. DOI: 10.2174/138920111795909096

Vander Heiden, M.G., Lunt, S.Y., Dayton, T.L., Fiske, B.P., Israelsen, W.J., Mattaini, K.R., Vokes, N.I., Stephanopoulos, G., Cantley, L.C., Metallo, C.M., Locasale, J.W. Metabolic pathway alterations that support cell proliferation. (2011) Cold Spring Harbor Symposia on Quantitative Biology. 76:325-34. DOI: 10.1101/sqb.2012.76.010900

Metallo, C.M., Vander Heiden, M.G. Metabolism strikes back: metabolic flux regulates cell signaling. (2010) Genes & Development. 24(24):2717-22. DOI: 10.1101/gad.2010510

Hiller, K., Metallo, C.M., Kelleher, J.K., Stephanopoulos, G. Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry. (2010) Analytical Chemistry. 82(15):6621-8. DOI: 10.1021/ac1011574

Metallo, C.M., Ji, L., de Pablo, J.J., Palecek, S.P. Directed differentiation of human embryonic stem cells to epidermal progenitors. (2010) Methods in Molecular Biology. 585:83-92. DOI: 10.1007/978-1-60761-380-0_7

Metallo, C.M., Azarin, S.M., Moses, L.E., Ji, L., de Pablo, J.J., Palecek, S.P. Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs. (2010) Tissue Eng Part A. 16(1):213-23. DOI: 10.1089/ten.TEA.2009.0325

Metallo, C.M., Walther, J.L., Stephanopoulos, G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. (2009) J Biotechnol. 144(3):167-74. DOI: 10.1016/j.jbiotec.2009.07.010

Metallo, C.M., Vodyanik, M.A., de Pablo, J.J., Slukvin, I.I., Palecek, S.P. The response of human embryonic stem cell-derived endothelial cells to shear stress. (2008) Biotechnol Bioeng. 100(4):830-7. DOI: 10.1002/bit.21809

Metallo, C.M., Azarin, S.M., Ji, L., de Pablo, J.J., Palecek, S.P. Engineering tissue from human embryonic stem cells. (2008) J Cell Mol Med. 12(3):709-29. DOI: 10.1111/j.1582-4934.2008.00228.x

Metallo, C.M., Ji, L., de Pablo, J.J., Palecek, S.P. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. (2008) Stem Cells. 26(2):372-80. DOI: 10.1634/stemcells.2007-0501

Metallo, C.M., Mohr, J.C., Detzel, C.J., de Pablo, J.J., Van Wie, B.J., Palecek, S.P. Engineering the stem cell microenvironment. (2007) Biotechnol Prog. 23(1):18-23. DOI: 10.1021/bp060350a

Xie, L., Metallo, C., Warren, J., Pilbrough, W., Peltier, J., Zhong, T., Pikus, L., Yancy, A., Leung, J., Auniņs, J.G., Zhou, W. Large-scale propagation of a replication-defective adenovirus vector in stirred-tank bioreactor PER.C6 cell culture under sparging conditions. (2003) Biotechnol Bioeng. 83(1):45-52. DOI: 10.1002/bit.10644

Xie, L., Pilbrough, W., Metallo, C., Zhong, T., Pikus, L., Leung, J., Auniņs, J.G., Zhou, W. Serum-free suspension cultivation of PER.C6(R) cells and recombinant adenovirus production under different pH conditions. (2002) Biotechnol Bioeng. 80(5):569-79. DOI: 10.1002/bit.10443